The CRICS network

CRICS is a group of ICU wards of which the objective is to develop and professionalise clinical research in critically ill patients especially in the sepsis field.

The network was established in 2006 with 6 centers: Angoulême, La Roche Sur Yon, Limoges, Orléans, Poitiers, and Tours. In July 2008, the CRICS network enabled all of the centers to participate in the clinical trial “MIDEX”. The CRICS network has grown in France and Europe with the inclusion of 4 new centers: Argenteuil, Brussels, Dijon and Montauban in 2010, 2 centers in 2012: Strasbourg NHC, Strasbourg Hautepierre hospital, 1 center in 2013: Ottignies (Belgium) and in 2015, 3 centers join the network: Dinant-Godinne, Nantes and Marseille. The coordination was ensured by the Limoges center from 2006 to 2012 and since September 2012 by the Tours center (Dr Emmanuelle Mercier).

CRICS is a unique organisation in France as well as in Europe in the sepsis field. All the members of the CRICS network have prioritised clinical research in the heart of their ICU’s. The network aims to open up in Europe in order to increase their visibility and power of inclusion while maintaining good clinical practice. They play an active part in the clinical research medical training: Clinical Research Investigator Inter University Diploma (Download the file). In order to evaluate and guarantee the quality of clinical research in our network, an external audit was carried out in 2013.

The tasks of CRICS are to ensure the quantity and quality of recruitment in the different trials, to inform the clinical staff on clinical research and to raise awareness and responsibility of the investigators in reliance to good clinical practice (GCP).

The span of investigation of the CRICS network is principally centered on the theme of sepsis in critically ill patients. Other themes are also developed in the network such as ventilator associated pneumonia, ARDS, acute circulatory failure, neurological resuscitation, cardiac arrest, nutrition, ethics, innovative therapies (immunotherapy) and thrombosis.

The CRICS network has a number of assets to ensure and elaborate clinical research.

1- Network recruitment capacity and logistical and technical resources:

378 beds in 16 centers: 297 beds in ICU and 81 beds in the continuing care units for a total of more than 15 000 admissions of which 60% are ventilated patients.

Download the file

 The network members have the logistical and technical resources in which they can guarantee the quality in order to conduct clinical trials in emergency situations.

Download the file

2 - Network organisation:

  • Central coordination
  • A scientific council was set up in 2011 in order to promote the scientific aspect of clinical research with a priority axis in the field of sepsis.
  • There is a charter which concerns the general functioning of the network and another for the scientific council.
  • Organisation of coordination meetings: annual seminar, quarterly meetings and regular (updates either by teleconference or by e-mail).
  • Centralised feasibility: dispatch of the confidential agreements to the coordinating center which remains the contact and diffusion point for the other participating centers, thus saving time for the sponsor.
  • Organisation of joint staff training.
  • A six monthly newsletter is sent to all the members.
  • Network extranet site: available to all the network centers since May 2012.
  • Centralisation of additional costs: assessment of the cost implications for an industrial clinical trial is ensured by the network’s coordinating investigator.

3 - Partnership with other networks or entities:

Key partners:

  • CIC of CHRU Limoges
  • CIC of CHRU Tours
  • INSERM of CHRU Limoges
  • INSERM of CHRU Tours
  • Clinical Investigation Center sepsis network
  • IMI (Innovative Medicines Initiative)
  • F-CRIN (French Clinical Research Infrastructure Network)
  • TRIGGERSEP (TRIal Group for Global Evaluation and Research in SEPsis) labelled by INSERM under F-CRIN
  • CeNGEPS:  Crics labelled by CENGEPS from 2007 to 2014