• Intravenous zanamivir or oral oseltamivir for hospitalised patients with influenza: an international, randomised, double-blind, double-dummy, phase 3 trial. Marty FM, Vidal-Puigserver J, Clark C, Gupta SK, Merino E, Garot D, Chapman MJ, Jacobs F, Rodriguez-Noriega E, Husa P, Shortino D, Watson HA, Yates PJ, Peppercorn AF. Lancet Respir Med. 2017 Feb;5(2):135-146. doi: 10.1016/S2213-2600(16)30435-0. Pneumopathy
  • Video Laryngoscopy vs Direct Laryngoscopy on Successful First-Pass Orotracheal Intubation Among ICU Patients: A Randomized Clinical Trial. Lascarrou JB, Boisrame-Helms J, Bailly A, Le Thuaut A, Kamel T, Mercier E, Ricard JD, Lemiale V, Colin G, Mira JP, Meziani F, Messika J, Dequin PF, Boulain T, Azoulay E, Champigneulle B, Reignier J; Clinical Research in Intensive Care and Sepsis (CRICS) Group. JAMA. 2017 Jan 24. doi: 10.1001/jama.2016.20603. Neuro-reanimation
  • A randomized trial of the amikacin fosfomycin inhalation system for the adjunctive therapy of Gram-negative ventilator-associated pneumonia: IASIS Trial. Kollef MH, Ricard JD, Roux D, Francois B, Ischaki E, Rozgonyi Z, Boulain T, Ivanyi Z, János G, Garot D, Koura F, Zakynthinos E, Dimopoulos G, Torres A, Danker W, Montgomery AB. Chest. 2016 Nov 24. pii: S0012-3692(16)62463-7. doi: 10.1016/j.chest.2016.11.026. Pneumopathy
  • Predicting arterial blood gas and lactate from central venous blood analysis in critically ill patients: a multicentre, prospective, diagnostic accuracy study. Boulain T, Garot D, Vignon P, Lascarrou JB, Benzekri-Lefevre D, Dequin PF; Clinical Research in Intensive Care and Sepsis (CRICS) Group. Br J Anaesth. 2016 Sep;117(3):341-9. Acute circulatory insufficiency
  • Early High-Dose Erythropoietin Therapy After Out-of-Hospital Cardiac Arrest: A Multicenter, Randomized Controlled Trial. Cariou A, Deye N, Vivien B, Richard O, Pichon N, Bourg A, Huet L, Buleon C, Frey J, Asfar P, Legriel S, Narcisse S, Mathonnet A, Cravoisy A, Dequin PF, Wiel E, Razazi K, Daubin C, Kimmoun A, Lamhaut L, Marx JS, de la Garanderie DP, Ecollan P, Combes A, Spaulding C, Barat F, Ben Boutieb M, Coste J, Chiche JD, Pène F, Mira JP, Treluyer JM, Hermine O, Carli P; Epo-ACR-02 Study Group. J Am Coll Cardiol. 2016 Jul 5;68(1):40-9. Neuro-reanimation
  • Early Detection of Disseminated Intravascular Coagulation During Septic Shock: A Multicentre Prospective Study. Delabranche X, Quenot JP, Lavigne T, Mercier E, François B, Severac F, Grunebaum L, Mehdi M, Zobairi F, Toti F, Meziani F, Boisramé-Helms J; on behalf to the Clinical Research in Intensive Care and Sepsis Network. Crit Care Med. 2016 Jun 17. Sepsis
  • Design and conduct of the activated protein C and corticosteroids for human septic shock (APROCCHSS) trial. Annane D, Buisson CB, Cariou A, Martin C, Misset B, Renault A, Lehmann B, Millul V, Maxime V, Bellissant E; APROCCHSS Investigators for the TRIGGERSEP Network. Ann Intensive Care. 2016 Dec;6(1):43. Sepsis
  • Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients. Kalfon P, Le Manach Y, Ichai C, Bréchot N, Cinotti R, Dequin PF, Riu-Poulenc B, Montravers P, Annane D, Dupont H, Sorine M, Riou B; CGAO-REA Study Group. Crit Care. 2015 Apr 8;19:153. Nutrition
  • Tight computerized versus conventional glucose control in the ICU: a randomized controlled trial. Kalfon P, Giraudeau B, Ichai C, Guerrini A, Brechot N, Cinotti R, Dequin PF, Riu-Poulenc B, Montravers P, Annane D, Dupont H, Sorine M, Riou B; CGAO-REA Study Group. Intensive Care Med. 2014 Feb;40(2):171-81. Nutrition
  • Acute cor pulmonale during protective ventilation for acute respiratory distress syndrome: prevalence, predictors, and clinical impact. Mekontso Dessap A, Boissier F, Charron C, Bégot E, Repessé X, Legras A, Brun-Buisson C, Vignon P, Vieillard-Baron A. Intensive Care Med. 2015 Dec 9. ARDS
  • McGRATH MAC videolaryngoscope versus Macintosh laryngoscope for orotracheal intubation in intensive care patients: the randomised multicentre MACMAN trial study protocol. Bailly A, Lascarrou JB, Le Thuaut A, Boisrame-Helms J, Kamel T, Mercier E, Ricard JD, Lemiale V, Champigneulle B, Reignier J; Clinical Research in Intensive Care and Sepsis (CRICS) Group. BMJ Open. 2015 Dec 23;5(12):e009855. Neuro-reanimation
  • Therapeutic hypothermia after nonshockable cardiac arrest: the HYPERION multicenter, randomized, controlled, assessor-blinded, superiority trial. Lascarrou JB, Meziani F, Le Gouge A, Boulain T, Bousser J, Belliard G, Asfar P, Frat JP, Dequin PF Gouello JP, Delahaye A, Hssain AA, Chakarian JC, Pichon N, Desachy A, Bellec F, Thevenin D, Quenot JP, Sirodot M, Labadie F, Plantefeve G, Vivier D, Girardie P, Giraudeau B, Reignier J; Clinical Research in Intensive Care and Sepsis (CRICS) Group and HYPERION Study Group. Scand J Trauma Resusc Emerg Med. 2015 Mar 7;23:26. Neuro-reanimation
  • Talactoferrin in Severe Sepsis: Results From the Phase II/III Oral tAlactoferrin in Severe sepsIS Trial. Vincent JL, Marshall JC, Dellinger RP, Simonson SG, Guntupalli K, Levy MM, Singer M, Malik R; OUTCOMEREA Study Group. Damas P, Dive A, Dugernier T, Foret F, Laterre PF, Oeyen S, Vander Laenen M, Vincent JL, Chittock D, Dhar A, Hall RI, Kumar A, Muscedere J, Paunovic BN, Siddiqui FS, Wood GG, Jensen S, François B, Cracco C, Roustan J, Mercier E, Boulain T, Mercat A, Mira JP, Fiancette M, Timsit J, Chatellier D, Bohe J, Meier-Hellmann A, Reinhart K, Peckelsen C, Meier J, Bar-Levie Y, Bursztein S, Einav-Bromiker S, Levin PD, Singer P, Beishuizen A, Gerritsen RT, Pickkers P, Rozendaal FW, Schoonderbeek FJ, Spronk PE, Alvarez Lerma F, Martinez Sagasti F, Artigas Raventos A, Rodriguez AH, Nava J, Alvarez Lerma F, Brealey D, Jauregui-Peredo L, Amin D, Schein RM, Zeno BR, Figueroa-Casas JB, Guntupalli KK, Huang DT, Krell KE, Seibert AF, Steingrub JS, Taylor RW, Tillis W, Willms DC, Wright PE, Dellinger RP, Levy MM, Morris P, Rivers EP, Seneff M, Kinasewitz G, Margolis BD, Dean NC, Kalil AC, Schmidt GA, Douglas IS, Lo T, Bernard A. Crit Care Med. 2015 Sep;43(9):1832-1838. Sepsis
  • Acute respiratory distress syndrome (ARDS)-associated acute cor pulmonale and patent foramen ovale: a multicenter noninvasive hemodynamic study. Legras A, Caille A, Begot E, Lhéritier G, Lherm T, Mathonnet A, Frat JP, Courte A, Martin-Lefèvre L, Gouëllo JP, Mercier E, Vignon P; ARCO and CRICS network. Crit Care. 2015 Apr 17;19(1):174. ARDS
  • Prevalence of low central venous oxygen saturation in the first hours of intensive care unit admission and associated mortality in septic shock patients: a prospective multicentre study. Boulain T, Garot D, Vignon P, Lascarrou JB, Desachy A, Botoc V, Follin A, Frat JP, Bellec F, Quenot JP, Mathonnet A, Dequin PF; Clinical Research in Intensive Care and Sepsis Group. Crit Care. 2014 Nov 6;18(6):609. Acute circulatory insufficiency
  • Impact of early enteral versus parenteral nutrition on mortality in patients requiring mechanical ventilation and catecholamines: study protocol for a randomized controlled trial (NUTRIREA-2). Brisard L, Le Gouge A, Lascarrou JB, Dupont H, Asfar P, Sirodot M, Piton G, Bui HN, Gontier O, Hssain AA, Gaudry S, Rigaud JP, Quenot JP, Maxime V, Schwebel C, Thévenin D, Nseir S, Parmentier E, El Kalioubie A, Jourdain M, Leray V, Rolin N, Bellec F, Das V, Ganster F, Guitton C, Asehnoune K, Bretagnol A, Anguel N, Mira JP, Canet E, Guidet B, Djibre M, Misset B, Robert R, Martino F, Letocart P, Silva D, Darmon M, Botoc V, Herbrecht JE, Meziani F, Devaquet J, Mercier E, Richecoeur J, Martin S, Gréau E, Giraudeau B, Reignier J1. Trials. 2014 Dec 23;15:507. Nutrition
  • Volume expansion in the first 4 days of shock: a prospective multicentre study in 19 French intensive care units. Boulain T, Boisrame-Helms J, Ehrmann S, Lascarrou JB, Bouglé A, Chiche A, Lakhal K, Gaudry S, Perbet S, Desachy A, Cabasson S, Geneau I, Courouble P, Clavieras N, Massanet PL, Bellec F, Falquet Y, Réminiac F, Vignon P, Dequin PF, Meziani F. Intensive Care Med. 2014 Dec 2. Acute circulatory insufficiency
  • Global Prospective Epidemiologic and Surveillance Study of Ventilator-Associated Pneumonia due to Pseudomonas aeruginosa*. Kollef MH1, Chastre J, Fagon JY, François B, Niederman MS, Rello J, Torres A, Vincent JL, Wunderink RG, Go KW, Rehm C. Crit Care Med. 2014 Oct;42(10):2178-87. Pneumopathy
  • Assessment of panobacumab as adjunctive immunotherapy for the treatment of nosocomial Pseudomonas aeruginosa pneumonia. Que YA, Lazar H, Wolff M, François B, Laterre PF, Mercier E, Garbino J, Pagani JL, Revelly JP, Mus E, Perez A, Tamm M, Rouby JJ, Lu Q, Chastre J, Eggimann P. Eur J Clin Microbiol Infect Dis. 2014 May 24. Innovative therapy : immunotherapy
  • Pseudomonas aeruginosa serotypes in nosocomial pneumonia: prevalence and clinical outcomes. Lu Q, Eggimann P, Luyt CE, Wolff M, Tamm M, François B, Mercier E, Garbino J, Laterre PF, Koch H, Gafner V, Rudolf MP, Mus E, Perez A, Lazar H, Chastre J, Rouby JJ. Crit Care. 2014 Jan 15;18(1):R17. Innovative therapy : immunotherapy
  • Designing and conducting a randomized trial for pandemic critical illness: the 2009 H1N1 influenza pandemic. Annane D, Antona M, Lehmann B, Kedzia C, Chevret S; CORTIFLU Investigators; CRICs; AZUREA; REVA/SRLF networks. Intensive Care Med.2012 Jan;38(1):29-39. Pneumopathy
  • Induced Hypothermia in Severe Bacterial Meningitis: A Randomized Clinical Trial. Mourvillier B, Tubach F, van de Beek D, Garot D, Pichon N, Georges H, Lefevre LM, Bollaert PE, Boulain T, Luis D, Cariou A, Girardie P, Chelha R, Megarbane B, Delahaye A, Chalumeau-Lemoine L, Legriel S, Beuret P, Brivet F, Bruel C, Camou F, Chatellier D, Chillet P, Clair B, Constantin JM, Duguet A, Galliot R, Bayle F, Hyvernat H, Ouchenir K, Plantefeve G, Quenot JP, Richecoeur J, Schwebel C, Sirodot M, Esposito-Farèse M, Le Tulzo Y, Wolff M. JAMA. 2013 Oct 8. Neuro-reanimation
  • Intermittent pneumatic compression to prevent venous thromboembolism in patients with high risk of bleeding hospitalized in intensive car units : the CIREA1 randomized trial. Vignon P, Dequin PF, Renault A, Mathonnet A, Paleiron N, Imbert A, Chatellier D, Gissot V, Lhéritier G, Aboyans V, Prat G, Garot D, Boulain T, Diehl JL, Bressollette L, Delluc A, Lacut K and the Clinical Research in Intensive Care and Sepsis Group (CRICS). Intensive Care Med. 2013 May;39(5):872-80. Thrombosis
  • Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa : A randomized, double-blind, placebo-controlled trial. Francois B, Luyt CE, Dugard A, Wolff M, Diehl JL, Jaber S, Forel JM, Garot D, Kipnis E, Mebazaa A, Misset B, Andremont A, Ploy MC, Jacobs A, Yarranton G, Pearce T, Fagon JY, Chastre J. Crit Care Med. 2012 Aug;40(8):2320-6. Innovative therapy : immunotherapy
  • Prone positioning in severe acute respiratory distress syndrome. Guérin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, Clavel M, Chatellier D, Jaber S, Rosselli S, Mancebo J, Sirodot M, Hilbert G, Bengler C, Richecoeur J, Gainnier M, Bayle F, Bourdin G, Leray V, Girard R, Badoi L, Ayzac L for the PROSEVA study group. N Engl J Med. 2013 Jun 6;368(23):2159-68. ARDS
  • Prevalence and prognostic value of acute cor pulmonale and patent foramen ovale in ventilated patients with the acute respiratory distress syndrome. A multicenter study. Lhéritier G, Legras A, Kalfon P, Mathonnet A, Frat JP, Courte A, Martin-Lefevre L, Goello JP, Amiel JB, Caille A, Vignon P for ARCO and the CRICS network. Intensive Care Med. 2013 Jul 17. ARDS
  • Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation : two randomized controlled trials. Jacob SM, Ruokonen E, Grounds RM, Sarapohja T, Garrat C, Pocock SJ, Bratty JR, Takala J ; Dexmedetomidine for Long-Term Sédation investigators. JAMA. 2012;307(11):1151-1160. Neuro-reanimation
  • Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early feeding : a randomized controlled trial. Reignier J, Mercier E, Le Gouge A, Boulain T, Desachy A, Bellec F, Clavel M, Frat JP, Plantefeve G, Quenot JP, Lascarrou JB, CRICS group. JAMA. 2013 Jan 16;309(3):249-56. Nutrition
  • Safety and Pharmacokinetics of Intravenous Zanamivir Treatment in Hospitalized Adults With Influenza: An Open-label, Multicenter, Single-Arm, Phase II Study. Marty FM, Man CY, van der Horst C, Francois B, Garot D, Mánez R, Thamlikitkul V, Lorente JA, Alvarez-Lerma F, Brealey D, Zhao HH, Weller S, Yates PJ, Peppercorn AF. J Infect Dis. 2013 Sep 18. Pneumopathy
  • Pharmacokinetics and safety of panobacumab : specific adjunctive immunotherapy in critical patients with nosocomial Pseudomonas aeruginosa O11 pneumonia. Lu Q, Rouby JJ, Laterre PF, eggimann P, Dugard A, Giamarellos-Bourboulis E, Mercier E, Garbino J, Luyt CE, Chastre J, Georgescu-Kyburz V, Rudolf M, Gafner V, Lazar H, Koch H, Perez A, Krämer S, Tamm M. J Antimicrob Chemother. 2011 May;66(5):1110-6. Innovative therapy : immunotherapy
  • Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia. Wunderink R, Laterre PF, Francois B, Perrotin D, Artigas A, Otero Vidal L, Lobo S, San Juan J, Hwang S, Dugernier T, LaRosa S, Wittebole X, Dhainault JF, Doig C, Mendelson M, Zwingelstein C, Su G, Opal S on behalf of the CAPTIVATE group. Am J Respir Crit Care Med. 2011 Jun 1;183(11):1561-8. Innovative therapy : immunotherapy, Pneumopathy
  • Effect of Eritoran, an Antagonist of MD2-TLR4, on mortality in patients with severe sepsis. Opal S, Laterre PF, Francois B, LaRosa S, Angus D, Mira JP, Wittebole X, Dugernier T, Perrotin D, Tidswell M, Jauregui L, Krell K, Pachl J, Takahashi T, Peeckelsen C, Cordasco E, Chang CS, Oeyen S, Aikawa N, Maruyama T, Schein R, Kalil A, Van Nuffelen M, Lynn M, Rossignol D, Gogate J, Roberts M, Wheeler J, Vincent JL for the ACCESS study group. JAMA. 2013 Mar 20;309(11):1154-62. Sepsis
  • Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated). Shorr AF, Janes JM, Artigeas A, Tenhunen J, Wyncoll DL, Mercier E, Francois B, Vincent JL, Vangerow B, Heiselman D, Leishman AG, Zhu YE, Reinhart K, RESPOND investigators. Crit Care. 2010;14(6):R229. Sepsis